Technical Data
N2108-75N
Neuregulin 1, Recombinant, Human (NRG1, NDF)
10ug
50ug
Growth Factors, Cytokines Storage: -70CShipping: Dry Ice
Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. Research on molecular level discovered that recombinant neuregulin could make disturbed myocardial cell structure into order and strengthen the connection between myocardial cells by intercalated discs re-organization.

Biological Activity:
Fully biologically active when compared to standard. The activity measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions corresponding to a specific activity of 1.2 x 10e4 units/mg.

Endotoxin: 1EU/ug as determined by LAL method.

Storage and Stability:
Lyophilized powder may be stored at -20C. Reconstitute with distilled water, containing 0.1% BSA . Aliquot and store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
7,005 D
Source: E. coli
Purity: ~96% by SDS-PAGE and HPLC analyses.
Form: Supplied as a lyophilized powder in PBS, pH 7.0, 0.5% HAS, 2% mannitol. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1mg/ml.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.