Technical Data
O5305-03
Ochratoxin A
1mg
Biochemicals Storage: -20CShipping: Blue Ice
Ochratoxin A is a chlorinated benzopyran coupled to the amino acid phenylalanine, produced by several Aspergillus and Penicillium sp. associated with food spoilage. Ochratoxins are widely distributed in the environment and are known to be nephrotoxic, teratogenic and possibly carcinogenic. Ochratoxin A may act by induction of DNA strand breaks, sister chromatid exchanges, DNA adduct formation, or reactive oxygen but the mechanism of action as a toxin is not yet resolved. At the molecular level, ochratoxin A has been shown to specifically inhibit NK cell activity, increase growth of transplantable tumor cells in mice, increase apoptosis, activate c-Jun N terminal kinase in human kidney epithelial cells, and block metaphase/anaphase
transition. It also inhibits plasminogen activator inhibitor-2 production by human blood mononuclear cells.

Source: Aspergillus ochraceus MST-FP2005

Apperance: Pale yellow solid

Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
303-47-9

Molecular Formula:
C20H18ClNO6

Molecular Weight:
403.8
Source: Aspergillus ochraceus MST-FP2005
Purity: ~95%

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Mycotoxins. Part II. The constitution of ochratoxins A, B, and C, metabolites of Aspergillus ochraceus Wilh. Van der Merwe K. J. et al., J.C.S. 1965, 7083. 2. Ochratoxin A inhibits the production of tissue factor and plasminogen activator inhibitor-2 by human blood mononuclear cells: Another potential mechanism of immune-suppression. Rossiello M.R et al., Tox. Appl. Pharmacol. 2008, 229, 227. 3. Ochratoxin A: Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics? Rached E. et al., Toxicol. Sci. 2006, 92, 78. 4. Selective immunosuppression in mice of natural killer cell activity by ochratoxin A. Luster M.I. et al., Canc. Res. 1987, 47, 2259.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.