Technical Data
O5305-03A
Ochratoxin A
Description:
Ochratoxin A is a chlorinated benzopyran coupled to the amino acid phenylalanine, produced by several Aspergillus and Penicillium sp. associated with food spoilage. Ochratoxins are widely distributed in the environment and are known to be nephrotoxic, teratogenic and possibly carcinogenic. Ochratoxin A may act by induction of DNA strand breaks, sister chromatid exchanges, DNA adduct formation, or reactive oxygen but the mechanism of action as a toxin is not yet resolved. At the molecular level, ochratoxin A has been shown to specifically inhibit NK cell activity, increase growth of transplantable tumor cells in mice, increase apoptosis, activate c-Jun N terminal kinase in human kidney epithelial cells, and block metaphase/anaphase transition. It also inhibits plasminogen activator inhibitor-2 production by human blood mononuclear cells.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
1ml-20CBlue IceRabbit
Concentration:
~5mg/ml
Immunogen:
Ochratoxin A conjugated to BSA.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes Ochratoxin A. Crossreactivity: Ochratoxin B: 1%, BSA: <0.1%.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Bonel, L. et al. (2010) Ochratoxin A nanostructured electrochemical immunosensors based on polyclonal antibodies and gold nanoparticles coupled to the antigen Anal.Methods: epub ahead of print