Technical Data
Opioid Receptor, delta, CT, aa360-372
The function of the delta-opioid receptors has not been determined. However, recent studies in rodents have linked delta-opioid receptor antagonists with prevention of morphine tolerance and dependence without relinquishing mu-opioid antinociception. In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.

Suitable for ELISA, Immunohistochemistry and Western Blot. Other applications have not been tested.

Recommended Dilution:
Immunohistochemistry (ABC): 1:800 Stains specific cells in various regions of PLP fixed rat brain sections known to express the delta opioid receptor.
Western Blot: 1:800; Band at ~55kD is observed using whole rat brain homogenate.
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile PBS, 10mg/ml BSA. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
100ul-20CBlue IceHumanRabbit
Not determined
Synthetic peptide corresponding to the carboxyl terminal of human delta opioid receptor covalently attached to a carrier protein.
Supplied as a lyophilized powder. Reconstitute with 100ul sterile PBS, 10mg/ml BSA.
Recognizes human Delta Opioid Receptor (360-372): 100%; Delta Opioid Receptor: 60%; Mu Opioid Receptor (391-398), Mu Opioid Receptor, Kappa Opioid Receptor (346-380), Kappa Opioid Receptor: 0%
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.