Technical Data
O7030-15E
Opioid Receptor, delta (OPRD, Delta Type Opioid Receptor, Delta Type Opioid Receptor DOR-1, DOR-1, mDOR, Nbor, Opioid Receptor delta 1, Opioid Receptor delta-1, OPRD1)
Description:
This protein functions as an inhibitor for neurotransmittors release by reducing calcium ion currents and increasing potassium ion conductance. Jordan and Devi (1999) provided biochemical and pharmacologic evidence for the heterodimerization of 2 fully functional opioid receptors, kappa (OPRK1; 165196) and delta. This results in a new receptor that exhibits ligand binding and functional properties that are distinct from those of either receptor. Furthermore, the kappa-delta heterodimer synergistically binds highly selective agonists and potentiates signal transduction. Pharmacologic and electrophysiologic evidence indicates that opioid receptors are involved in the mechanism of heroin dependence. Thus, opioid receptors are appropriate candidate genes for case-control association studies of heroin dependence Xu et al. (2002).

Applications:
Suitable for use in Immunocytochemistry. Other applications not tested.

Recommended Dilution:
Immunocytochemistry: 1:1000.
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add glycerol (40-50%) and aliquot. Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
50ul4°C (-20°C Glycerol)Blue IceRatRabbit
Concentration:
Not determined
Immunogen:
A Synthetic peptide sequence corresponding to aa-TACTPSDGPGGGAAA, (358-372) of rat Opioid Receptor, delta. Cellular Localization: Multi-pass membrane protein.
Purity:
Serum
Form
Supplied as a liquid in 0.05% sodium azide.
Specificity:
Recognizes rat Opioid Receptor. Species Crossreactivity: mouse. Species sequence homology: human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Xu K et al. Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. Am J Med Genet 110:45-50 (2002). Jordan BA & Devi LA G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399:697-700 (1999). Arvidsson U et al. delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. J Neurosci 15:1215-35 (1995). Abood ME et al. Molecular cloning and expression of a delta-opioid receptor from rat brain. J Neurosci Res 37:714-9 (1994). Dado RJ et al. Immunofluorescent identification of a delta (delta)-opioid receptor on primary afferent nerve terminals. Neuroreport 5:341-4 (1993).