		Technical Data
O7030-15N	OPRD1 (Delta-type Opioid Receptor, D-OR-1, DOR-1, OPRD)

Description:
G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that activate intracellular signaling cascades and undergo endocytosis, recycling, or degradation upon stimulation. The mu, delta and kappa opioid receptors are GPCRs of the nervous system, which control pain, stress, and addictive behaviors. The delta opioid receptor (DOR-1) is the stereoselective receptor for enkephalins and inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Alternate names: OPRD1; Opioid Receptor, Delta-1.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.

Positive Control:
Human, mouse and rat brain lysate

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~1mg/ml

Immunogen:

Synthetic peptide corresponding to aa361-372 TPSDGPGGGAAA of the human DOR-1 protein.

Purity:

Purified by immunoaffinity chromatography.

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

Specificity:

Recognizes human DOR-1. Species Crossreactivity: mouse and rat.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Evans, C. J., Keith, D. E. Jr., Morrison, H., Magendzo, K. and Edwards, R.H. Cloning of a delta opioid receptor by functional expression. Science 258(5090), 1952-1955 (1992). 2. Gaveriaux, C., Peluso, J., Simonin, F., Laforet, J. and Kieffer, B. Identification of kappa- and delta-opioid receptor transcripts in immune cells. FEBS Lett. 369(2-3), 272-276 (1995). 3. Scherrer, G., Tryoen-Toth, P., Filliol, D., Matifas, A., Laustriat, D., Cao, Y.Q., Basbaum, A.I., Dierich, A., Vonesh, J.L., Gaveriaux-Ruff, C. and Kieffer, B.L. Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc. Natl. Acad. Sci. U.S.A. 103(25), 9691-9696 (2006).