Technical Data
OPRM1 (Mu-type Opioid Receptor, M-OR-1, MOR-1, Opioid Receptor B, Oprm1, Ror-b)
The mu-type opioid receptor known as OPRM1, is a 60-70kD variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. OPRM1 is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. OPRM1 activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, OPRM1 is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor, Nociceptin/Orphanin Receptor, Neurokinin 1 Receptor, Somatostatin Receptor 2, Cannabinoid Receptor 1, CCR5, and the a2A-Adrenergic Receptor. Rat OPRM1 shares 94% and 98% aa sequence identity with human and mouse OPRM1.

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
MabIgG2A12K148Affinity Purified
100ug-20CBlue IceRatMouse
~0.5mg/ml after reconstitution
Synthetic peptide corresponding to aa385-398 from rat OPRM1.
Purified by Protein A/G affinity chromatography.
Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
Recognizes rat OPRM1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.