Technical Data
O8238-40
7-Oxostaurosporine (Antibiotic BMY 41950, Antibiotic RK 1409)
1mg
Biochemicals Storage: 4C/-20CShipping: Blue Ice
7-Oxostaurosporine is the oxidised and highly fluorescent analogue of Antibiotics UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. It inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells and possesses comparable activity against tumor cells lines to Antibiotic UCN-01. Despite its close relationship to Antibiotic UCN-01 and staurosporine, limited access to the metabolite has restricted a more complete investigation of its properties.

DMSO, DMF, methanol and ethanol. Limited water solubility

CAS Number:
141196-69-2

Molecular Formula:
C28H24N4O4

Molecular Weight:
480.52199999999999136
Source: Streptomyces sp.
Purity: > 98% by HPLC
Form: Yellow solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I Taxonomy and biological activity. Osada, H. et al., J. Antibiot. 1992, 45, 189. 2. A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II Fermentation, Isolation, Physico-chemical properties and structure. Koshino H. et al., J. Antibiot. 1992, 45, 195.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.