Technical Data
P3355
Persephin (PSP, Neurotrophic Factor)
5ug
20ug
Molecular Biology Storage: -20CShipping: Blue Ice
Human Persephin (PSP) a novel neurotrophic factor is about 40% identical to GDNF and Neurturin (NTN). Persephin, like GDNF and NTN, promotes the survival of ventral midbrain dopaminergic neurons in culture. It also supports the survival of motor neurons in culture. Recombinant Human Persephin is a homodimeric 20.6kD protein consisting of two identical subunits each containing 96 amino acid residues.

Biological Activity : Human Persephin induces RET phosphorylation using a concentration range of 0.1-1.0ng/ml. Human Persephin binds to mammalian GFRa4 with the Kd of 100pM. Other members of the GDNF family (Artemin, GDNF and Neurturin) do not bind to mammalian GFRa4.

AA Sequence : ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with ddH2O. Aliquot and store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Country of Origin:
USA

Molecular Weight:
20.6kD
Source: E. coli
Purity: 98% by SDS-PAGE. Endotoxin: 0.1ng/ug (1EU/ug).
Form: Supplied as a lyophilized powder from 0.3X PBS, pH 7.2 Reconstitute with sterile, ddH2O to 0.1-1mg/ml.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.