Technical Data
Phosphodiesterase 4B (PDE4B, PDEIVB, cAMP-specific 3',5'-cyclic Phosphodiesterase 4B, DPDE4, PDE32)
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Positive Control: Mouse Brain Lysate

Suitable for use in ELISA (peptide) and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGAffinity Purified
100ug-20CBlue IceHumanGoat
Synthetic peptide: C-DIDIATEDKSPVDT, representing the C Terminus of the human protein according to NP_002591.2; NP_001032418.1; NP_001032416.1; NP_001032417.1.
Purified by immunoaffinity chromatography.
Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
This antibody is expected to recognize all reported isoforms (NP_002591.2, NP_001032418.1, NP_001032416.1 and NP_001032417.1). Species Crossreactivity: Mouse. Other Species have not been tested. Expected crossreactivity based upon sequence homology: Human, Mouse, Rat
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ, Houslay MD, Blackwood DH, Muir WJ, Porteous DJ. . DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.. Science. 2005 Nov 18;310(5751):1187-91. . PMID: 16293762