Technical Data
P4072-11H
Phosphodiesterase 11A (PDE11A, Dual 3',5'-Cyclic-AMP and -GMP Phosphodiesterase 11A, cAMP and cGMP Phosphodiesterase 11A)
Description:
PDE11A is a 100kD cyclic nucleotide phosphodiesterase, which catalyzes the hydrolysis of cAMP and cGMP. PDE11A is thought to be involved in multiple physiological processes in various organs. PDE11A is calmodulin dependent and exists as four splice variants (PDE11A1-PDE11A4). Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia.

Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:2000
Western Blot: 0.5-1.5ug/ml
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanGoat
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to C-NSFKESMEKSSYSD, from the internal region of PDE11A.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity:
Recognizes human PDE11A. Species sequence homology: Canine, mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.