Technical Data
Phosphotrienin (Fostriecin, Antibiotic CI 920, Antibiotic CL 1565A, Antibiotic PD 110161, NSC 339638)
Biochemicals Storage: -20CShipping: Blue Ice
Fostriecin is the most fully characterized member of a family of phosphate esters of a triene antibiotic. The antitumor potential of fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent research has focused on this metabolite's selective inhibition of protein phosphatase PP2A.

Purity: 95% by HPLC, isolated as the sodium salt

Solubility: Soluble in water, optimial stability in aqueous buffered solutions at pH 6.5. Note: hydrolysis of the phosphate ester will result from inappropriate storage.

Related to: Sultriecin

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Streptomyces sp.
Form:Supplied as a white powder.

Form: Supplied as a white powder.

Storage and Stability: Lyophilized powder may be stored at -20C. Reconstitute to nominal volume by adding sterile buffer. Aliquot and store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Walsh. AH et al., FEBS Lett. 416: 230 (1997) . 2. Guo, X,W et al. EMBO J, 14:976 (1995)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.