Technical Data
P4075-25
Phosphotrienin (Fostriecin, Antibiotic CI 920, Antibiotic CL 1565A, Antibiotic PD 110161, NSC 339638)
100ug
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Technical Data |
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P4075-25 |
Phosphotrienin (Fostriecin, Antibiotic CI 920, Antibiotic CL 1565A, Antibiotic PD 110161, NSC 339638) |
100ug |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Fostriecin is the most fully characterized member of a family of phosphate esters of a triene antibiotic. The antitumor potential of fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent research has focused on this metabolite's selective inhibition of protein phosphatase PP2A. Purity: 95% by HPLC, isolated as the sodium salt Solubility: Soluble in water, optimial stability in aqueous buffered solutions at pH 6.5. Note: hydrolysis of the phosphate ester will result from inappropriate storage. Related to: Sultriecin CAS Number: 87810-56-8 Molecular Formula: C19H27O9P Molecular Weight: 430.4 |
Source: Streptomyces sp. Form:Supplied as a white powder. Form: Supplied as a white powder. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile buffer. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Walsh. AH et al., FEBS Lett. 416: 230 (1997) . 2. Guo, X,W et al. EMBO J, 14:976 (1995)
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