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Technical Data |
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P4085-10 |
PIAS2 (Protein Inhibitor of Activated STAT2, Androgen Receptor-interacting Protein 3, ARIP3, DAB2-interacting Protein, DIP, E3 SUMO Protein Ligase PIAS2, Msx-interacting Zinc Finger Protein, Miz1, PIAS-NY Protein, PIASX, Protein Inhibitor of Activated Sta |
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Description: Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. Two transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Affinity purified using their peptide immunogen and are known to give low background staining in a western blot. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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