Technical Data
R1120-35
Rap2B (Member of RAS oncogene family, Ras-related protein Rap-2b precursor)
Description:
Rap2B is a member of the small GTPase superfamily and ras family of proteins. Unlike
normal ras proteins that have a nontransforming glutamine residue at aa 61, Rap2B
has a threonine residue in that position. This change makes the intrinsic GTPase
activity for Rap2B lower, thereby allowing it to exist in the activated state for a longer
period of time than normal ras proteins. Aggregation of platelets by thrombin results in
the activation of Rap2B in a Ca 2+ and PI3 kinase-dependent manner.

Applications:
Suitable for Western Blot. Other applications not tested.


Storage:
Lyophilized samples are stable for twelve months from date of receipt when stored
at -20C to -70C. Upon reconstitution, the antibody can be stored at 2-8C for
1 month without detectable loss of activity. Reconstituted antibody can also be
aliquotted and stored frozen at -20C to -70C in a manual defrost freezer for
six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
TypeIsotypeCloneGrade
MabIgG2a9H175Affinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
E. coli-derived rhRap2B.
Purity:
Purified by Protein G affinity chromatography.
Form
0.2um sterile-filtered solution in PBS with 5% trehalose.
Specificity:
This antibody detects endogenous human Rap2B at 22 kDa using Western blot. The antibody does not cross-react with recombinant human Rap2A.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.