all-trans Retinoic Acid (Vitamin A Acid, ATRA, Tretinoin)
|Biochemicals||Storage: -20°CShipping: RT|
Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Light and temperature sensitive.
Method for Determining Identity:
Proton NMR Spectroscopic Analysis.
SiO2: Hexane: Ethyl acetate:1:1; Visualized with UV and AMCS; Single spot; Rf=0.6.
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.