		Technical Data
R1998-10M	RHOC (Rho-related GTP-binding Protein RhoC, Rho cDNA Clone 9, h9, ARH9, ARHC)

Description:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Mab	IgG2b,k	2E12	Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Mouse

Concentration:

As reported

Immunogen:

RHOC (AAH07245, 1-194aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD.

Purity:

Purified.

Form

Supplied as a liquid in PBS, pH 7.2.

Specificity:

Recognizes human RHOC.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1.Epidermal Growth Factor Stimulates Human Trophoblast Cell Migration through Rho A and Rho C Activation. Han J, Li L, Hu J, Yu L, Zheng Y, Guo J, Zheng X, Yi P, Zhou Y.Endocrinology. 2010 Feb 11. [Epub ahead of print]