Technical Data
S0097-70E
SARM, CT (Sterile alpha and TIR Motif-containing Protein 1, SARM1, FLJ36296, KIAA0524, Sterile alpha and Armadillo Repeat Protein, Sterile alpha Motif Domain-containing Protein 2, SAM Domain-containing Protein 2, SAMD2, Tir-1 Homolog)
Description:
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.

Applications:
Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGHighly Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to aa near the C-terminus of human SARM.
Purity:
Purified by Ion Exchange chromatography.
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity:
Recognizes human SARM. Species Crossreactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Vogel, SN. et al. Mol. Interv. 3, 466 (2003). 2. Takeda, K. et al. Annu. Rev. Immunol. 21, 335 (2003). 3. Janeway, CA Jr. et al. Annu. Rev. Immunol. 20, 197 (2002). 4. O'Neill, LAJ. et al. Trends in Imm. 24 286 (2003). 5. McGettrick, AF. et al. Mol Imm. 41, 577 (2004).