Technical Data
S1001-23R
Serotonin Receptor 7 (5-Hydroxytryptamine (Serotonin) Receptor 7, 5-Hydroxytryptamine Serotonin Receptor 7, 5-HT7, 5-HT-7, 5HT7 Receptor, 5-HT-X, GPRFO, HTR7, Serotonin 5-HT-7 Receptor)
Description:
Receptors for serotonin (5-hydroxytryptamine, 5-HT) are classified into seven major classes (5-HTR1-7), based on structural, functional and pharmacological criteria (Hoyer et al, 1994). The 5-HT7 receptor (5-HT7R) is a seven-transmembrane-domain G-protein-coupled receptor that has important roles in regulating diverse biological process in the central and peripheral nervous systems (reviewed in Hedlund and Sutcliffe, 2004). Receptors for serotonin (5-hydroxytryptamine, 5-HT) are classified into seven major classes (5-HT1-7), based on structural, functional and pharmacological criteria (Hoyer et al, 1994). Sequence alignment shows a high degree of interspecies 5-HT7R homology (>90%), and a low homology with other 5-HTRs.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Brain

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
100ug-20CBlue IceRatRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa13-28 of the rat 5-HT7R (Genbank Accession no. AAA42134.1).
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity:
Recognizes rat Serotonin 5-HT7 Receptor. Species Crossreactivity: canine, human, mouse. Species sequence homology: porcine.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Hedlund PB and JC Sutcliffe. 2004. Functional, molecular and pharmacological advances in 5-HT7 receptor research. Trends Pharmacol Sci. 25:481-486. 2. Hoyer D, DE Clarke, JR Fozard, PR Hartig, GR Martin, EJ Mylecharane et al. 1994. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacological Reviews 46:157-203.