Technical Data
S1013-88H
SIRT4 (Sirtuin 4, Sirtuin-4, Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 4 (S. cerevisiae), Sirtuin Type 4, NAD-dependent Deacetylase Sirtuin 4, Silent Mating Type Information Regulation 2 Homolog, Sir2 Like 4, Sir2-like 4, SIR2 Like Pro
Description:
SIRT4 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:8000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG15i86Affinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
ovalbumin-conjugated synthetic peptide corresponding to N-terminal aa1-50 of human silent information regulator 2 homolog (Sirt4)
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2.
Specificity:
Recognizes human Sirt4.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Smith, J.S. et. al. (2002) Methods Enzymol. 353, 282 - 300. 2. Frye, R. (2000) Biochem. Biophys. Res. Commun. 273, 793 - 798. 3. Frye, R. (1999) Biochem. Biophys. Res. Commun. 260, 273 - 279.