Technical Data
SIRT4 (Sirtuin 4, Sirtuin-4, Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 4 (S. cerevisiae), Sirtuin Type 4, NAD-dependent Deacetylase Sirtuin 4, Silent Mating Type Information Regulation 2 Homolog, Sir2 Like 4, Sir2-like 4, SIR2 Like Pro
SIRT4 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:8000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG15i86Affinity Purified
50ug-20CBlue IceHumanMouse
ovalbumin-conjugated synthetic peptide corresponding to N-terminal aa1-50 of human silent information regulator 2 homolog (Sirt4)
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, pH 7.2.
Recognizes human Sirt4.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Smith, J.S. et. al. (2002) Methods Enzymol. 353, 282 - 300. 2. Frye, R. (2000) Biochem. Biophys. Res. Commun. 273, 793 - 798. 3. Frye, R. (1999) Biochem. Biophys. Res. Commun. 260, 273 - 279.