		Technical Data
S1013-88H7	SIRT4 (Sirt4 Protein)

Description:
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are highly conserved proteins and have important roles in the regulation of metabolism, inflammation, cellular survival growth and differentiation. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD-dependent protein ADP-ribosyl transferase which catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. SIRT4 localizes to mitochondria, inhibits glutamate dehydrogenase (GLUD1), and may involve in the regulation of insulin secretion.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1-4ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Rat	Rabbit

Concentration:

~0.5mg/ml

Immunogen:

Synthetic peptide corresponding to aa72 from rat SIRT4.

Purity:

Purified by affinity chromatography.

Form

Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 5mM EDTA, 0.01% thimerosal, 30% glycerol.

Specificity:

Recognizes rat SIRT4. Species Crossreactivity: human and mouse.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.