		Technical Data
S1013-88K2	SIRT6 (Sirtuin 6, Sirtuin-6, Mono-ADP-ribosyltransferase Sirtuin-6, SIR2-like Protein 6, SIR2L6)

Description:
Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human ageing.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Cellular Localization: Nuclear

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Type	Isotype	Clone	Grade
Pab			Affinity Purified

Size		Storage	Shipping	Source	Host
100ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

~1mg/ml

Immunogen:

A synthetic peptide made to an internal region of the human SIRT6 protein (within residues 250-350). [Swiss-Prot Q8N6T7].

Purity:

Purified by immunoaffinity chromatography.

Form

Tris-citrate/phosphate (pH 7-8)

Specificity:

Species Crossreactivity: Human. Other species have not been tested. The immunogen used for the production of this antibody shows 78% homology with the mouse protein and 71% homology with the rat protein.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Michishita, E., et al. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Bio. Cell. 16: 4623-4635 (2005)