Technical Data
S1014-15J
SKP1A (S-phase Kinase-associated Protein 1, Cyclin-A/CDK2-associated Protein p19, p19skp1, p19A, RNA Polymerase II Elongation Factor-like Protein, Organ of Corti Protein 2, OCP-2, Organ of Corti Protein II, OCP-II, Transcription Elongation Factor B, SIII,
Description:
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq]

Applications:
Suitable for use in ELISA, Immunofluorescence, and Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1,000
ELISA: 1ug/ml-3ng/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2a11C758Affinity Purified
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
Recombinant protein corresponding to a portion of amino acids within aa53-161 of human SKP1A.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
Specificity:
Recognizes human SKP1A.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.