		Technical Data
S1040-01G	SOCS 1, CT (Suppressor of Cytokine Signalling 1, Janus kinase (JAK) binding protein, STAT-induced STAT inhibitor, SSI-1)

Description:
Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5-1ug/ml
Optimal dilution determined by the researcher.

Positive control:
K562 cell lysate

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

As reported

Immunogen:

Synthetic peptide corresponding to 15 amino acids near the carboxy terminus of human SOCS1 (Genbank accession No. CAB92528).

Purity:

Purified by immunoaffinity chromatography.

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

Specificity:

Reacts with human, mouse and rat SOCS1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1.Rakesh. K., et al., (2005), “Controlling cytokine signaling by constitutive inhibitors”, Biochem. Pharm., 70: 649-657
2.O’Shea, J.J., et al., (2002), “Cytokine signaling in 2002: new surprises in the Jak/Stat pathway:, Cell, 109: S121-S131
3.Kile, B.T., et al, (2002), “The SOCS box: a tale of destruction and degradation”, Trends Biochem. Sci., 27: 235-241
4.Mansell, A., et al., (2006), “Suppressor of cytokine signaling 1 negatively mediates Toll-like receptor signaling by mediating Mal degradation”, Nat. Immunol., 7: 148-155