Technical Data
SOCS 1, NT (Suppressor of Cytokine Signaling 1, SOCS1, SOCS-1, Cytokine Inducible SH2 Protein 1, CISH1, Janus Kinase Binding Protein, JAK-binding Protein, JAB, STAT-induced STAT Inhibitor 1, SSI1, SSI-1, TEC-interacting Protein 3, TIP3, TIP-3)
Suppressor of cytokine signalling 1 (SOCS1) is a 24kD member of the Suppressor of cytokine signalling family. SOCS1 acts downstream of cytokine receptors and plays a role in the negative regulation of cytokine signalling. It acts mainly on the Janus kinase (JAK)/signal transducers and activators of transcription-3 (STAT3) pathway but also inhibits signalling by cytokines such as insulin and toll-like receptors. Furthermore SOCS1 is involved in ubiquitin-dependent protein degradation, plays a role in T cell activation and in the regulation of IL-6, IL-4, IL-12 and IL-15. SOCS1 is expressed ubiquitously and at elevated levels in the spleen, small intestine and peripheral blood leukocytes.

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
100ug-20CBlue IceHumanRabbit
A 17aa peptide sequence near the amino terminus of human SOCS1.
Purified by immunoaffinity chromatography.
Supplied as a liquid in PBS, 0.02% sodium azide.
Recognizes human SOCS1. Species Crossreactivity: mouse, rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Davey, G. et al. (2006) SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation. Tissue Antigens. 67:1-9. 2. Rakesh, K. et al. (2005) Controlling cytokine signaling by constitutive inhibitors. Biochem Pharmacol. 70:649-57.