Technical Data
S1040-03L
SOCS 3 (Suppressor of Cytokine Signalling 3, SOCS3, SOCS-3, ATOD4, Cytokine-induced SH2 Protein 3, CIS3, CIS-3, Cish3, E2a Pbx1 Target Gene in Fibroblasts 10, EF-10, MGC71791, STAT-induced STAT Inhibitor 3, SSI3, SSI-3) (Azide Free)
Description:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq]

Applications:
Suitable for use in ELISA and Immunohistochemistry (paraffin). Other applications not tested.

Recommended Dilution:
ELISA: 1ug/ml-3ng/ml
Immunohistochemistry (paraffin): 1.5ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2b11C773Affinity Purified
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
Recombinant protein corresponding to aa1-226 of human SOCS3.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
Specificity:
Recognizes human SOCS-3.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.