		Technical Data
S5380-14A	Spectrin Beta 3 (Beta III Spectrin, KIAA0302, Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, Spectrin Non-erythroid beta Chain 2, SPTBN2, Spinocerebellar Ataxia 5, SCA5, SCA 5)

Description:
Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. Spectrin-beta IIIs have been recognized as ataxia disease genes and their mutations cause spinocerebellar ataxia type 5 (SCA5).

Applications:
Suitable for use in Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Positive Control: HeLa whole cell lysate

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Type	Isotype	Clone	Grade
Pab			Affinity Purified

Size		Storage	Shipping	Source	Host
25ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

~1mg/ml

Immunogen:

The epitope recognized by this antibody maps to a region between residues 2150 and 2200 of human spectrin, beta, non-erythrocytic 2 (spinocerebellar ataxia 5 ) using the numbering given in entry NP_008877.1. Homology: 100% with human, mouse, and rat prote

Purity:

Purified by immunoaffinity chromatography.

Form

Tris-citrate/phosphate buffer, pH 7 to 8

Specificity:

Species Crossreactivity: This antibody reacts with human. Other species have not been tested.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.