Technical Data
S8000-02
Substance P (NK, Neurokinin)
Description:
The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.

Applications:
Suitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry: 1:250-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
50ul-20CBlue IceRatGuinea pig
Concentration:
Not determined
Immunogen:
Synthetic peptide corresponding to aa1-11, CRPKPQQFFGLM, of rat Substance P.
Purity:
Serum
Form
Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
Specificity:
Recognizes rat Substance P. Species Crossreactivity: Human, mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Ljungdahl, T., et al. Distribution of Substance P Like Immunoreactivity in the Central Nervous System of the Rat-II. Light Microscopic Localization in Relation to Catecholamine-Containing Neurons. Neuroscience. 3: 945-976, 1978.