Technical Data
Substance P Receptor, aa385-407 (NK1 Receptor, Neurokinin Receptor)
Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.

Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry: 1:100-1:1000
Western Blot: 1:500 detected the truncated form of Substance P Receptor on 10ug of mouse brain membrane lysates
Optimal dilution to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
50ul-20CBlue IceMouseRabbit
Not Determined
Synthetic peptide that corresponds to aa385-407 from the COOH-terminus of the mouse/rat Substance P Receptor (NK-1R).
Liquid. No preservatives added.
Recognizes mouse Substance P Receptor (NK-1R). Species Crosseactivity: rat and guinea pig.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Piggins, et al., J. Comparative Neurology 438: 50-65 (2001). 2. Vigna, et al., J. Neuroscience 14(2): 834-845 (1994). 3. Mantyh, et al., Science 278: 275-279 (1997). 4. Solomon, I.C., Respiratory Physiology & Neurobiology 139: 1-20 (2003). 5. Matyas, F., et al., European Journal of Neuroscience 19: 1243-1256 (2004).