		Technical Data
S8000-51	Substance P Receptor, aa385-407 (NK1 Receptor, Neurokinin Receptor)

Description:
The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine, headache and allergy-induced asthma.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry: 1:100-1:1000
Optimal dilution to be determined by researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Type	Isotype	Clone	Grade
Pab	IgG		Serum

Size		Storage	Shipping	Source	Host
50ul		4°C (-20°C Glycerol)	Blue Ice	Mouse	Rabbit

Concentration:

Not determined

Immunogen:

Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH-terminus of the mouse/rat Substance P Receptor (NK-1R).

Purity:

Serum

Form

Liquid. No preservatives added.

Specificity:

Recognizes mouse Substance P Receptor (NK-1R). Species Crosseactivity: Rat and guinea pig.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Piggins, et al., J. Comparative Neurology 438: 50-65 (2001). 2. Vigna, et al., J. Neuroscience 14(2): 834-845 (1994). 3. Mantyh, et al., Science 278: 275-279 (1997). 4. Solomon, I.C., Respiratory Physiology & Neurobiology 139: 1-20 (2003). 5. Matyas, F., et al., European Journal of Neuroscience 19: 1243-1256 (2004).