Technical Data
Substance P Receptor, aa385-407 (NK1 Receptor, Neurokinin Receptor)
The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine, headache and allergy-induced asthma.

Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry: 1:100-1:1000
Optimal dilution to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
50ul4C (-20C Glycerol)Blue IceMouseRabbit
Not determined
Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH-terminus of the mouse/rat Substance P Receptor (NK-1R).
Liquid. No preservatives added.
Recognizes mouse Substance P Receptor (NK-1R). Species Crosseactivity: Rat and guinea pig.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Piggins, et al., J. Comparative Neurology 438: 50-65 (2001). 2. Vigna, et al., J. Neuroscience 14(2): 834-845 (1994). 3. Mantyh, et al., Science 278: 275-279 (1997). 4. Solomon, I.C., Respiratory Physiology & Neurobiology 139: 1-20 (2003). 5. Matyas, F., et al., European Journal of Neuroscience 19: 1243-1256 (2004).