Technical Data
Syntaxin 1A (Syntaxin 1A (Brain), STX1A, HGNC:11433, HPC-1, Neuron Specific Antigen HPC1, Neuron-specific Antigen HPC-1, p35-1, STX1)
Please note this product is expected to recognize the products of 2 different genes.
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995).[supplied by OMIM]

Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Positive Control: Mouse brain lysate

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGAffinity Purified
100ug-20CBlue IceHumanGoat
Synethtic peptide: KDRTQELRTAKD-C, representing the N Terminus of the human protein according to NP_004594.1; NP_443106.1;.
Purified by immunoaffinity chromatography.
Supplied as a liquid in TBS, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Species Crossreactivity: Mouse. Other species have not been tested. Expected crossreactivity based upon sequence homology: Human, Mouse, Rat, canine
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Kang Y, Leung YM, Manning-Fox JE, Xia F, Xie H, Sheu L, Tsushima RG, Light PE, Gaisano HY. Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.J Biol Chem. 2004 Nov 5;279(45):47125-31. Epub 2004 Aug 31. PMID: 15339904