Technical Data
STXBP1 (Syntaxin-binding Protein 1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1, Protein unc-18 Homolog A, Unc-18A, p67, UNC18A)
STXBP1 (Syntaxin-binding protein 1; also p67, Munc18-1, N-Sec1 and Unc18A) is a 67kD member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins. It is expressed in a variety of cells, presumably in those that exhibit granule exocytosis, and likely participates in (synaptic) granule release. Ligands for STXBP1 include STX1A, 2 and 3, and it is possible that STXBP1 both suppresses STX activity, and serves as an anchor for STX-mediated vesicle fusion. Human STXBP1 is 594aa in length. It contains one SEC1 domain (aa41-575). Phosphorylation at Ser313 may stimulate granule release. There is one splice variant that shows a 28aa substitution for aa576-594. This is restricted to neural tissue. Over aa80-226, human and
mouse STXBP1 are absolutely identical in amino acid sequence.

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.
100ug-20CBlue IceHumanRabbit
As reported
STXBP1 (NP_003156.1, 1-603aa) full-length human protein.
Supplied as a liquid in PBS, pH 7.2.
Recognizes human STXBP1. Species Crossreactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.