Technical Data
S9205-80B
Syntaxin-binding Protein 1 (STXBP1, FLJ37475, MUNC18-1, NSEC1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1, Protein unc-18 Homolog A, Unc-18A, p67, RBSEC1, UNC18, UNC18A)
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Technical Data |
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S9205-80B |
Syntaxin-binding Protein 1 (STXBP1, FLJ37475, MUNC18-1, NSEC1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1, Protein unc-18 Homolog A, Unc-18A, p67, RBSEC1, UNC18, UNC18A) |
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Description: Munc-18, otherwise known as STXBP1, is a syntaxin-binding, pre-synaptic protein and member of the STXBP/UNC-18/SEC1 family, expressed in the brain and spinal cord, and at significantly high levels in neuronal axons. Munc-18 is a vital component of the synaptic vesicle fusion protein complex, playing a critical role in calcium-dependent neurotransmitter release, and in the regulation of the exocytosis of neurons and neuroendocrine cells. Studies have shown that isoform a of Munc-18 (Munc 18-1/Munc18a), acts as a regulator of insulin secretion from pancreatic beta cells. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Brain lysates Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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