		Technical Data
S9500-01E	Synuclein, alpha (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)

Description:
Alpha Synuclein is a protein of 140aa expressed abundantly in the brain. a-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Mutations of the a-synuclein gene have been linked to Parkinson disease.

Applications:
Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.

Recommended Dilutions:
Western Blot: 1:1000
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

Not Determined

Immunogen:

Synthetic peptide corresponding to the the carboxy-terminal sequence of human alpha-Synuclein.

Purity:

Purified by Protein A affinity and peptide affinity chromatography.

Form

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Specificity:

Recognizes human alpha-Synuclein at ~18kD. May crossreact with beta synuclein. Species Crossreactivity: rat, mouse and monkey

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Goldberg, M.S. & Lansbury Jr., P.T., Nat. Cell Biol. 2: 115–119 (2000).