Technical Data
S9500-01E
Synuclein, alpha (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)
Description:
Alpha Synuclein is a protein of 140aa expressed abundantly in the brain. a-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Mutations of the a-synuclein gene have been linked to Parkinson disease.

Applications:
Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.

Recommended Dilutions:
Western Blot: 1:1000
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.

Positive Controls:
HeLa, 293, rat brain and mouse brain cell extracts.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
Not Determined
Immunogen:
Synthetic peptide corresponding to the C-terminal sequence of human alpha-Synuclein (P37840).
Purity:
Purified by Protein A affinity and peptide affinity chromatography
Form
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol
Specificity:
Recognizes human alpha-Synuclein at ~18kD. May crossreact with beta synuclein. Species Crossreactivity: rat, mouse and monkey
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Goldberg, M.S. & Lansbury Jr., P.T., Nat. Cell Biol. 2: 115119 (2000).