Technical Data
S9500-03M
Synuclein, alpha (SNCA, Alpha Synuclein, MGC110988, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, PARK1, PARK4, Parkinson Disease Familial 1, PD1)
Description:
Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.

Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
Mab9E787Ascites
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanMouse
Concentration:
Not determined
Immunogen:
Ni-NTA purified truncated recombinant SNCA expressed in E. Coli strain BL21 (DE3).
Purity:
Ascites
Form
As reported
Specificity:
Species Crossreactivity: Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. J. Johnson, S. M. Hague, M. Hanson Neurology, Aug 2004; 63: 554 ¨C 556
2. Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie Protein Pept Lett. 2006;13(4):385-90.