Technical Data
S9500-21T
Synuclein, alpha (Alpha-synuclein, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, SNCA, NACP, PARK1)
Description:
alpha-Synuclein is a 19kD protein composed of 140aa and a member of the synuclein family. Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from alpha- synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of gamma-synuclein correlates with disease progression.

Applications:
Suitable for use in Dot Blot. Other applications not tested.

Recommended Dilution:
Dot Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanRabbit
Concentration:
~0.1mg/ml
Immunogen:
Synthetic peptide (GAG-S-IAA) corresponding to human alpha-Synuclein, surrounding serine 87.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.4, 0.05 % sodium azide.
Specificity:
Recognizes human alpha Synuclein.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Goldberg, M.S. et al (2000) Nat. Cell Biol. 2, 115-119. 2. Clayton DF. et al (1998) Trends Neurosci. Jun; 21(6):249-54.