Technical Data
S9500-21U
Synuclein, alpha, Phosphorylated (Ser87) (Alpha-synuclein, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, SNCA, NACP, PARK1)
Description:
alpha-Synuclein is a 19kD protein composed of 140aa and a member of the synuclein family. Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from alpha- synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of gamma-synuclein correlates with disease progression.

Applications:
Suitable for use in Dot Blot. Other applications not tested.

Recommended Dilution:
Dot Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
25ug-20CBlue IceHumanRabbit
Concentration:
~0.1mg/ml
Immunogen:
Synthetic phosphopeptide (GAG-pS-IAA) corresponding to human alpha-Synuclein, at the phosphorylated serine 87.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.4, 0.05 % sodium azide.
Specificity:
Recognizes human alpha Synuclein when Phosphorylated at Ser87.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Goldberg, M.S. et al (2000) Nat. Cell Biol. 2, 115-119. 2. Clayton DF. et al (1998) Trends Neurosci. Jun; 21(6):249-54.