Technical Data
T1030-40
Tau (Tau Protein, Microtubule-associated Protein, MAP)
Description:
Tau is a heterogeneous group of proteins that range in molecular weight from 50-67kD. They are instumental in the assembly of microtubules and have been associated with some disease states. In normal brain, tau is localized in the axons of the neurons but in some neuropathological lesions, it accumulates within the body of the neuron. Tau protein is a microtubule-associated protein predominantly localized to neuronal axons. Tau promotes tubulin polymerization and the stabilization of microtubules. Hyperphosphorylated forms of Tau are the major components of paired helical filaments (PHF) found in the neurofibrillary tangles which characterize Alzheimer’s disease. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG12Q125Ascites
SizeStorageShippingSourceHost
100ul4°C (-20°C Glycerol)Blue IceBovineMouse
Concentration:
Not Determined
Immunogen:
Bovine tau.
Purity:
Ascites
Form
Supplied as a liquid.
Specificity:
Recognizes bovine Tau. Species Crossreactivity: Rat and human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
PNAS.USA (1995) 92:10369–10373.