		Technical Data
T1041-04F	TAU, NT (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-Tau, PHF-tau, MAPTL, MTBT1, TAU, MAPT)

Description:
The microtubule-associated protein tau (MAPT) gene transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Applications:
Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.25mg/ml

Immunogen:

Synthetic peptide selected from the N-terminal region of human TAU (KLH).

Purity:

Purified by Protein G affinity chromatography.

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

Specificity:

Recognizes human TAU.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1.Yoshiyama, Y., et al., J. Neurosci. 23(33):10662-10671 (2003). 2.Horiguchi, T., et al., Am. J. Pathol. 163(3):1021-1031 (2003). 3.Gamblin, T.C., et al., Proc. Natl. Acad. Sci. USA 100(17):10032-10037 (2003). 4.Kraemer, B.C., et al., Proc. Natl. Acad. Sci. USA 100(17):9980-9985 (2003). 5.Yancopoulou, D., et al., J. Neuropathol. Exp. Neurol. 62(8):878-882 (2003).