Technical Data
T1041-04G
TAU, CT (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-Tau, PHF-tau, MAPTL, MTBT1, TAU, MAPT)
Description:
The microtubule-associated protein tau (MAPT) gene transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-1:1000
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide selected from the C-terminal region of human TAU (KLH).
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human TAU.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Yoshiyama, Y., et al., J. Neurosci. 23(33):10662-10671 (2003). 2.Horiguchi, T., et al., Am. J. Pathol. 163(3):1021-1031 (2003). 3.Gamblin, T.C., et al., Proc. Natl. Acad. Sci. USA 100(17):10032-10037 (2003). 4.Kraemer, B.C., et al., Proc. Natl. Acad. Sci. USA 100(17):9980-9985 (2003). 5.Yancopoulou, D., et al., J. Neuropathol. Exp. Neurol. 62(8):878-882 (2003).