Technical Data
TAU, CT (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-Tau, PHF-tau, MAPTL, MTBT1, TAU, MAPT)
The microtubule-associated protein tau (MAPT) gene transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence. Other applications not tested.

Recommended Dilution:
Western Blot: 1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Immunofluorescence: 1:10-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
200ul-20CBlue IceHumanRabbit
As reported
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 677-707 in the C-terminal region of human TAU, UniProt Accession #P10636. Cellular Localization: Cytoplasm, cytosol. Cell membrane.
Purified by ammonium sulfate precipitation.
Supplied as a liquid in PBS, 0.09% sodium azide.
Recognizes human TAU. Species sequence homology: Bovine, mouse, rat
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Yoshiyama, Y., et al., J. Neurosci. 23(33):10662-10671 (2003). 2.Horiguchi, T., et al., Am. J. Pathol. 163(3):1021-1031 (2003). 3.Gamblin, T.C., et al., Proc. Natl. Acad. Sci. USA 100(17):10032-10037 (2003). 4.Kraemer, B.C., et al., Proc. Natl. Acad. Sci. USA 100(17):9980-9985 (2003). 5.Yancopoulou, D., et al., J. Neuropathol. Exp. Neurol. 62(8):878-882 (2003).