Technical Data
T1041-04H
TAU, phosphorylated (Ser720) (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-Tau, PHF-tau, MAPTL, MTBT1, TAU, MAPT)
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Technical Data |
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T1041-04H |
TAU, phosphorylated (Ser720) (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-Tau, PHF-tau, MAPTL, MTBT1, TAU, MAPT) |
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Description: MAPT promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. Applications: Suitable for use in ELISA and Dot Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Dot Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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