Technical Data
Tissue Factor, Type 1
Tissue Factor (TF) is the membrane receptor for coagulation factors VII and VIIa and is a cell surface initiator of coagulation. It is the major molecule of this type and is critical for controlling hemostasis, thrombosis and inflammation. TF is not generally present in or on cells within the vasculature, but following vascular injury, blood can come into contact with TF expressed by extravascular cells, resulting in activation of the coagulation cascade.

Suitable for use in Dot and Western Blot, ELISA, Immunofluorescence, Immunohistochemistry and Flow Cytometry. Not suitable for Neutralization Studies. Other applications have not been tested.

Recommended Dilutions:
Western Blot: 1:1000
Immunohistochemistry: Frozen and paraffin sections.
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
100ug-20°CBlue IceHumanMouse
Purified human tissue factor apoprotein.
Supplied as a liquid in PBS, pH 7.4, 200mM mannitol.
Recognizes human tissue factor. Specific for epitope locus I. Epitope: within extracellular domain. Recognizes reduced and native, non-reduced human and primate tissue factor. Does not inhibit coagulation or neutralize Factor VII binding to tissue factor. Species Crossreactivity: primate. Does not recognize rabbit.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Morrissey, J.H., et al., Thromb. Res. 52: 247 (1988). 2. Contrino, J., et al., Am. J. Pathol. 145: 1315 (1994). 3. Veltrop, M.H., et al., Infect. Immun, 69: 2797 (2001). 4. Ott, I., et al., Arterioscler. Thromb. Vasc. Biol. 20: 874 (2000).