Technical Data
TLR10 (Toll Like Receptor 10)
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR10 is highly homologous to TLRs 1 and 6 and is most highly expressed in lymphoid tissues (6). Most recently genetic variation in TLR10 has been associated with contributing to asthma risk (7). It should be noted that TLR10 exists in mice only as a pseudogene (8).

Can be used for detection of TLR10 by Western blot at 0.5 to 1ug/ml. Despite its predicted size of ~90kD, a band correpsonding to TLR10 is observed at ~75kD in immunoblot assays.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20C or colder. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGHighly Purified
100ug-20CBlue IceHumanRabbit
Peptide corresponding to 14 amino acids near the middle of human TLR10 (GenBank accession no. AAQ88667)
Purified by Ion Exchange Chromatography.
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Recognizes human TLR10 (IN).
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Vogel SN, et al Mol. Interv. 2003; 3:466-77. 2. Takeda K, et al Annu. Rev. Immunol. 2003; 21:335-76. 3. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216. 4. O'Neill LAJ,et al Trends in Imm. 2003; 24:286-9. 5. McGettrick AF et al Mol Imm. 2004; 41:577-82. 6. Heil F, et al . Eur. J. Immunol. 2003; 33:2987-2997. 7. Heil F, et al Science 2004; 303:1526-9. 8. Jurk M, et al Nat. Immunol. 2002; 3:499.