		Technical Data
T8067-55C	TORC1, NT (CREB-regulated Transcription Coactivator 1, Transducer Of Regulated cAMP Response Element-binding Protein 1, TORC-1, Transducer of CREB Protein 1, Mucoepidermoid Carcinoma Translocated Protein 1, WAMTP1, MECT1, KIAA0616, CRTC1)

Description:
TORC1 is the transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. It Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation and Enhances the interaction of CREB1 with TAF4. It regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.25mg/ml

Immunogen:

Synthetic peptide selected from the N-terminal region of human TORC1 (KLH).

Purity:

Purified by immunoaffinity chromatography.

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

Specificity:

Recognizes human TORC1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Grimwood,J., et.al., Nature 428(6982), 529-535 (2004).