Technical Data
TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger Protein 119, RNF119)
TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670aa protein, is a human homolog of mouse Traf7 and consists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways.It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.

Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
100ug-20CBlue IceHumanRabbit
Synthetic peptide corresponding to aa334-356 (ELKFDVLDENQSKLSEDLMEFRR) of human TRAF7.
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Recognizes human TRAF7. Species sequence homology: mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Xu,L.G., Li,L.Y. and Shu,H.B. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. (2004) In press. 2. Morita MCB 16 (11); 5433-5444 (November 2005).