Technical Data
T8172-70A
TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger Protein 119, RNF119)
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Technical Data |
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T8172-70A |
TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger Protein 119, RNF119) |
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Description: TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670aa protein, is a human homolog of mouse Traf7 and consists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways.It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 0.1-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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