Technical Data
T8251
Transforming Growth Factor beta2, Recombinant, Human (TGF b2)
1ug
5ug
Growth Factors, Cytokines Storage: -20CShipping: Blue Ice
The three mammalian isoforms of TGF-beta, TGF-beta1, TGF-beta2, TGF-beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation, motility and synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth. It may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-beta2 is a 25kD protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

AA Sequence:
ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS

Storage and Stability: Lyophilized powder may be stored at -20C. Reconstitute with sterile ddH2O, 0.1% BSA. Aliquot and store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source: Baculovirus-infected High-5 insect cells
Purity: Highly purified (~ 98% by SDS-PAGE and HPLC)
Endotoxin: 0.1ng/ug (1EU/ug)
Form: Supplied as a lyophilized powder from sodium citrate, pH 3.5..Reconstitute with sterile ddH2O, 0.1% BSA to 0.1-1mg/ml.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.