Technical Data
T9100-25G6
TSC2, phosphorylated (Ser1798) (Tuberin, Tuberous Sclerosis 2 Protein, TSC4)
Description:
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Applications:
Suitable for use in ELISA and Dot Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Dot Blot: 1:500
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanRabbit
Concentration:
~0.25mg/ml
Immunogen:
Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser1798 of human TSC2 (KLH).
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human TSC2 phosphorylated at Ser1798.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Li, Y., et al., Mol. Cell. Biol. 24(18):7965-7975 (2004). 2.Karbowniczek, M., et al., J. Biol. Chem. 279(29):29930-29937 (2004). 3.Corradetti, M.N., et al., Genes Dev. 18(13):1533-1538 (2004). 4.Birchenall-Roberts, M.C., et al., J. Biol. Chem. 279(24):25605-25613 (2004). 5.Lewis, J.C., et al., J. Med. Genet. 41(3):203-207 (2004).