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Technical Data |
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T9161-56L |
Tumor Necrosis Factor Receptor Associated Factor 3 (TNF Receptor Associated Factor 3, TNF Receptor-associated Factor 3, TRAF 3, TRAF3, TRAF-3, CD40-associated Protein 1, CAP1, CAP-1, CD40 Binding Protein, CD40 BP, CD40BP, CD40 Receptor-associated Factor 1 |
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Description: MIP-T3 (microtubule-interacting protein associated with TRAF3) was originally identified in a yeast-two hybrid screen for proteins that interact with the tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3). As a microtubule binding protein, MIP-T3 has been found to mediate the binding of DISC1 (disrupted-in-schizophrenia 1) to microtubules. MIP-T3 has also been shown to associate with IL13 receptor alpha (IL-13Ralpha1) and function as an inhibitor of IL-13 signaling. Recently, studies of the C. elegans homolog of MIP-T3 (DYF-11) have revealed that MIP-T3 is critical to cilium development; and in mammalian cells, MIP-T3 has been found to localize to basal bodies and cilia. Alternate names for MIP-T3 include TRAF3IP1, interleukin13 receptor alpha1-binding protein 1, and TRAF3-interacting protein. Applications: Suitable for use in Immunoprecipitation. Not recommended for Western Blot analysis. Other applications not tested. Recommended Dilution: Immunoprecipitation: 2-5ug/mg lysate Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 3 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. |
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