Technical Data
U2800-01G
Urotensin II (Urotensin-2, U-II, UII, UTS2, UNQ525/PRO1068)
Description:
Urotensin II (U-II) is a cyclic heptapeptide that functions both as a potent vasoconstrictor and a neurotransmitter/neuromodulator. U-II circulates in the plasma as a zymogen, and is activated by the urotensin converting enzyme. U-II is the endogenous ligand for the G-protein coupled receptor 14 (GPR14), recently renamed the UT receptor.

Changes in the expression of U-II and its receptor have been associated with cardiovascular and renal diseases, including atherosclerosis, myocardial infarction, and diabetic nephropathy.

Applications:
Suitable for use in ELISA and Immunoassays. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Hybridoma:
Sp2/0 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG110F579Affinity Purified
SizeStorageShippingSourceHost
200ug-20CBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
Human Urotensin II.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Specificity:
Recognizes human Uroensin II.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Watanabe, T. et al. (2006) Human urotensin II as a link between hypertension and coronary artery disease. Hypertens. Res. 29: 375-387. 2. Nothacker, H.P. and Clark, S. (2005) From heart to mind. The urotensin II system and its evolving neurophysiological role. FEBS J. 272: 5694-5702. 3. Zhu, Y.C. et al. (2006) The role of urotensin II in cardiovascular and renal physiology and diseases. Br. J. Pharmacol. 148: 884-901.