Technical Data
Urotensin II (Urotensin-2, U-II, UII, UTS2, UNQ525/PRO1068)
Urotensin II (U-II) is a cyclic heptapeptide that functions both as a potent vasoconstrictor and a neurotransmitter/neuromodulator. U-II circulates in the plasma as a zymogen, and is activated by the urotensin converting enzyme. U-II is the endogenous ligand for the G-protein coupled receptor 14 (GPR14), recently renamed the UT receptor.

Changes in the expression of U-II and its receptor have been associated with cardiovascular and renal diseases, including atherosclerosis, myocardial infarction, and diabetic nephropathy.

Suitable for use in ELISA and Immunoassays. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Sp2/0 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG110F579Affinity Purified
200ug-20CBlue IceHumanMouse
Human Urotensin II.
Purified by Protein A affinity chromatography.
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Recognizes human Uroensin II.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Watanabe, T. et al. (2006) Human urotensin II as a link between hypertension and coronary artery disease. Hypertens. Res. 29: 375-387. 2. Nothacker, H.P. and Clark, S. (2005) From heart to mind. The urotensin II system and its evolving neurophysiological role. FEBS J. 272: 5694-5702. 3. Zhu, Y.C. et al. (2006) The role of urotensin II in cardiovascular and renal physiology and diseases. Br. J. Pharmacol. 148: 884-901.