Human vascular endothelium cadherin is an endothelium-specific cadherin localized at the intercellular junctions. The antibody can be used to investigate the functional role of VE-cadherin.
Suitable for use in Flow Cytometry. Other applications not tested.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
| Not Determined|
|Recombinant protein corresponding to aa1-258 of human VE-cadherin.|
|Purified by immunoaffinity chromatography|
|Supplied as a liquid in 50mM Tris, pH 7.3, 100mM sodium chloride, 1% BSA, 0.02% sodium azide. Labeled with Fluorescein isothiocyanate (FITC).|
|Recognizes human VE-cadherin. Species Crossreactivity: mouse, rat and bovine|
|Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.|
1. Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelium cadherin: D. Gulino, et al.; J. Biol. Chem. 273, 29786 (1998) 2. VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function: S. Iyer, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 286, L1143 (2004)|