Technical Data
W3035-40C
Wnt2B (Wingless-type MMTV Integration Site Family Member 2B, Protein Wnt-2b, Protein Wnt-13, Wnt13, XWnt2)
Description:
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in Human development as well as Human carcinogenesis. This gene produces two alternative transcript variants. WNT2B is a paralogue of WNT2 and encodes WNT2B1 and WNT2B2 isoforms due to alternative splicing using alternative promoter.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 5ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Human brain, cerebellum

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20°CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to the internal domain of human WNT2B.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
Specificity:
Recognizes human WNT2B. Species Sequence Homology: mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Skin Pharmacol Physiol 17:258-66 Molecular Analysis of the Effect of Topical Imiquimod Treatment of HPV 2/27/57-Induced Common Warts. Jacobs S, Grussendorf-Conen EI, Rösener I, and RĂ¼bben A. 2. J Comp Neurol 2004 Jun. 474:276-88 Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning. Abu-Khalil A, Fu L, Grove EA, Zecevic N, and Geschwind DH. 3. Osteoarthritis Cartilage 2004 Jun. 12:497-505 Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Yates KE. 4. Dev Biol 2004 Jan. 265:61-74 Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Burns RC, Fairbanks TJ, Sala F, De Langhe S, Mailleux A, Thiery JP, Dickson C, Itoh N, Warburton D, Anderson KD, and Bellusci S. 5. Cytogenet Genome Res 2003 . 101:84-9 Elucidation of correspondence between swine chromosome 4 and human chromosome 1 by assigning 27 genes to the ImpRH map, and development of microsatellites in the proximity of 14 genes. Hiraiwa H, Sawazaki T, Suzuki K, Fujishima-Kanaya N, Toki D, Ito Y, Uenishi H, Hayashi T, Awata T, and Yasue H.