		Technical Data
Z0728-50A	ZMPSTE24 (Zinc Metalloproteinase Ste24 Homolog, CAAX Prenyl Protease 1 Homolog, Farnesylated Proteins Converting Enzyme 1, FACE 1, FACE1, FACE-1, FLJ14968, MADB, Prenyl Protein Specific Endoprotease 1, STE24)

Description:
ZMPSTE24 is a zinc metalloprotease involved in the post-translational processing of LMNA precursors. Mutations in ZMPSTE24 have been associated with human diseases, often due to the accumulation of LMNA precursors. It is possible that ZMPSTE24, due to its association with LMNA, plays some role in human ageing.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Cellular Localization: Integral membrane, primarily ER

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Type	Isotype	Clone	Grade
Pab			Affinity Purified

Size		Storage	Shipping	Source	Host
25ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

~1mg/ml

Immunogen:

A synthetic peptide made to a C-terminal portion of the human ZMPSTE24 protein sequence (between residues 400-475). [Swiss-Prot O75844].

Purity:

Purified by peptide immunoaffinity chromatography.

Form

Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.

Specificity:

Recognizes human ZMPSTE24.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Corrigan, DP, et al. Biochem. J. 387: 129-138 (2005)
2. Young, SG, et al. Lipid Res. 46: 2531-2558 (2005)